NootkaShieldTM nootkatone production combines Evolva’s innovative yeast fermentation process with a proprietary conversion technique. This process results in a ≥99% pure source of nootkatone, with a more consistent batch quality.1 Whether you are developing a new product or reformulating an existing formula, Evolva is committed to supporting your needs.

NootkaShield from Evolva is a fresh alternative for the pest control industry.

Evolva’s NootkaShield provides manufacturers with consistent quality and purity, ingredient safety and reliable sourcing. If you need formulation support, please contact our technical team.

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NootkaShield properties

  • Purity ≥99%
  • EPA Reg. No.: 91873-1
  • Molecular weight: 218.34 g/mol
  • Appearance: pale yellow to white solid
  • CAS #: 4674-50-4
  • Toxicity: Class IV
  • Shelf life: 3 years

Nootkatone is approved as a flavor and fragrance1 in the USA, EU and Worldwide. Nootkatone has not been classified as a carcinogen by NTP, IARC, or OSHA2; or as being genotoxic (EFSA2, as well as Evolva’s studies). Class IV is the lowest possible EPA acute toxicity classification.

Extensive Safety Data

  • LD50 Oral (rat) > 5,000 mg/kg
  • LD50 Dermal (rabbit) > 5,000 mg/kg
  • LD50 Inhalation (rat) > 2.2 mg/L
  • NOAEL (oral, rat): 100 mg/kg/day in a 90-day study
  • NOAEL (prenatal developmental, oral, rat): 1,000 mg/kg/day
  • Primary eye irritation, in male rabbits: practically non-irritating
  • Dermal sensitization, mouse local lymph node assay: not a sensitizer at concentrations up to 50%
  • Primary dermal irritation, in male rabbits: slightly irritating
  • No sensitization observed in humans with high purity (>98%) nootkatone3

1. Flavor: USA (21 CFR 172.515); FEMA-GRAS 3166; Europe (Council of Europe No. 11164); Worldwide (JECFA, No. 1398); Fragrance: IFRA
2. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2015. Scientific Opinion on Flavouring Group Evaluation 213, Revision 2 (FGE.213Rev2): Consideration of genotoxic potential for α,β-unsaturated alicyclic ketones and precursors from chemical subgroup 2.7 of FGE.19. EFSA Journal 2015;13(9):4244, 49 pp. doi:10.2903/j.efsa.2015.4244.
Toxic Substances) guidelines
3. RIFM (Research Institute for fragrance materials) database

If you are interested in using NootkaShield for product formulation

we’d love to hear from you.

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