Product

NootkaShield™ nootkatone production combines Lallemand’s innovative yeast fermentation process with a proprietary conversion technique. This process results in a ≥99% pure source of nootkatone, with a more consistent batch quality.1 Whether you are developing a new product or reformulating an existing formula, Lallemand is committed to supporting your needs.

Product

NootkaShieldTM nootkatone production combines Lallemand’s innovative yeast fermentation process with a proprietary conversion technique. This process results in a ≥99% pure source of nootkatone, with a more consistent batch quality.1 Whether you are developing a new product or reformulating an existing formula, Lallemand is committed to supporting your needs.

Intro

Lallemand NootkaShieldâ„¢ is a fresh alternative for the pest control industry.

Lallemand NootkaShieldâ„¢ provides manufacturers with consistent quality and purity, ingredient safety and reliable sourcing. If you need formulation support, please contact our technical team.

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NootkaShieldâ„¢ properties

  • Purity ≥99%
  • EPA Reg. No.: 91873-1
  • Molecular weight: 218.34 g/mol
  • Appearance: pale yellow to white solid
  • CAS #: 4674-50-4
  • Toxicity: Class IV
  • Shelf life: 3 years

Nootkatone is approved as a flavor and fragrance1 in the USA, EU and Worldwide. Nootkatone has not been classified as a carcinogen by NTP, IARC, or OSHA2; or as being genotoxic (EFSA2, as well as Evolva’s studies). Class IV is the lowest possible EPA acute toxicity classification.

Safety

Extensive Safety Data

  • LD50 Oral (rat) > 5,000 mg/kg
  • LD50 Dermal (rabbit) > 5,000 mg/kg
  • LD50 Inhalation (rat) > 2.2 mg/L
  • NOAEL (oral, rat): 100 mg/kg/day in a 90-day study
  • NOAEL (prenatal developmental, oral, rat): 1,000 mg/kg/day
  • Primary eye irritation, in male rabbits: practically non-irritating
  • Dermal sensitization, mouse local lymph node assay: not a sensitizer at concentrations up to 50%
  • Primary dermal irritation, in male rabbits: slightly irritating
  • No sensitization observed in humans with high purity (>98%) nootkatone3

1. Flavor: USA (21 CFR 172.515); FEMA-GRAS 3166; Europe (Council of Europe No. 11164); Worldwide (JECFA, No. 1398); Fragrance: IFRA
2. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2015. Scientific Opinion on Flavouring Group Evaluation 213, Revision 2 (FGE.213Rev2): Consideration of genotoxic potential for α,β-unsaturated alicyclic ketones and precursors from chemical subgroup 2.7 of FGE.19. EFSA Journal 2015;13(9):4244, 49 pp. doi:10.2903/j.efsa.2015.4244.
Toxic Substances) guidelines
3. RIFM (Research Institute for fragrance materials) database